Effects of hypoxia on tumor metabolism

被引：114

作者：

Kim, Jung-whan

Gao, Ping

Dang, Chi V.

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA

来源：

CANCER AND METASTASIS REVIEWS | 2007年 / 26卷 / 02期

关键词：

tumor; hypoxia; hypoxia-inducible factor; metabolism; tumor bioenergetic;

D O I：

10.1007/s10555-007-9060-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rapidly growing tumors invariably contain hypoxic regions. Adaptive response to hypoxia through angiogenesis, enhanced glucose metabolism and diminished but optimized mitochondrial respiration confers survival and growth advantage to hypoxic tumor cells. In this review, the roles of hypoxia, the hypoxia inducible factors, oncogenes and tumor suppressors in metabolic adaptation of tumors are discussed. These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers.

引用

页码：291 / 298

页数：8

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