Studying human neurodegenerative diseases in flies and worms

被引：27

作者：

Feany, MB ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Neuropathol,Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2000年 / 59卷 / 10期

关键词：

Alzheimer disease; C; elegans; Drosophila; neurodegeneration; Parkinson disease; polyglutamine;

D O I：

10.1093/jnen/59.10.847

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Invertebrate models of several human neurodegenerative diseases have recently been described. These models faithfully replicate key neuropathological features of the human disorders. Because the basic cell biology of the nervous system is very similar in vertebrates and invertebrates, the sophisticated and rapid genetic analysis feasible in Drosophila and C. elegans promises significant insight into human neurodegenerative syndromes. In addition, the short lifespan, small size, and ease of culturing make worms and flies ideal for drug testing.

引用

页码：847 / 856

页数：10

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