Albumin and proximal tubular cells - beyond endocytosis

被引：15

作者：

Brunskill, NJ

机构：

[1] Univ Leicester, Fac Med & Biol Sci, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England

[2] Univ Leicester, Fac Med & Biol Sci, Dept Nephrol, Leicester LE1 9HN, Leics, England

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2000年 / 15卷 / 11期

关键词：

D O I：

10.1093/ndt/15.11.1732

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

A considerable body of evidence now implicates albumin and other filtered proteins in the pathogenesis of tubulointerstitial disease in the glomerulonephritides. Manipulation of the cell signalling and proinflammatory effects of albumin on PTC may prove an effective approach to therapy of progressive renal disease.

引用

页码：1732 / 1734

页数：3

共 23 条

[21]

Zoellner H, 1996, J CELL SCI, V109, P2571

[22] Protein overload stimulates RANTES production by proximal tubular cells depending on NF-KB activation [J].