Emerging strategies for managing differentiated thyroid cancers refractory to radioiodine

被引：30

作者：

Bulotta, Stefania ^{[1
]}

Celano, Marilena ^{[1
]}

Costante, Giuseppe ^{[1
,2
]}

Russo, Diego ^{[1
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus S Venuta, I-88100 Catanzaro, Italy

[2] Inst Jules Bordet Comprehens Canc Ctr, Dept Internal Med, Endocrinol Clin, Brussels, Belgium

来源：

ENDOCRINE | 2016年 / 52卷 / 02期

关键词：

Differentiated thyroid cancer; Radioiodine; Molecular targets; Re-differentiation strategies; Nanodevices; SODIUM-IODIDE SYMPORTER; PEGYLATED UNILAMELLAR LIPOSOMES; TYROSINE KINASE INHIBITORS; CARCINOMA CELL-LINES; NIS GENE-EXPRESSION; PHASE-II TRIAL; SODIUM/IODIDE SYMPORTER; STIMULATING HORMONE; RETINOIC ACID; DOUBLE-BLIND;

D O I：

10.1007/s12020-015-0830-4

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Efficient treatment of radio refractory thyroid cancer is still a major challenge. The recent identification of genetic and epigenetic alterations present in almost all differentiated tumors has revealed novel molecular targets, which can hopefully be exploited to create new treatments for these tumors. This review looks briefly at some of the innovative strategies currently being investigated for the treatment the radioiodine-resistant thyroid cancers.

引用

页码：214 / 221

页数：8

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