Sensing and Signaling in Antiviral Innate Immunity

被引：159

作者：

O'Neill, Luke A. J. ^{[1
]}

Bowie, Andrew G. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Immunol Res Ctr, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

CURRENT BIOLOGY | 2010年 / 20卷 / 07期

基金：

爱尔兰科学基金会;

关键词：

DOUBLE-STRANDED-RNA; CYTOSOLIC DNA; 5'-TRIPHOSPHATE RNA; VACCINIA VIRUS; DAI DLM-1/ZBP1; I INTERFERON; RESPONSES; INFLAMMASOME; RECOGNITION; ACTIVATION;

D O I：

10.1016/j.cub.2010.01.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viruses are detected by the innate immune system, leading to the initiation of the anti-viral immune response via the production of type I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress has been made over the past few years towards understanding the contribution of Toll-like receptors, RIG-I like receptors, NOD-like receptors and HIN-200 family members to viral detection. Furthermore, new complexities in the signaling pathways activated by these receptors continue to be revealed. Together, these new insights are leading to therapeutically useful information in the fight against viruses. © 2010 Elsevier Ltd. All rights reserved.

引用

页码：R328 / R333

页数：6

共 44 条

[1] RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate [J].

Ablasser, Andrea ;

Bauernfeind, Franz ;

Hartmann, Gunther ;

Latz, Eicke ;

Fitzgerald, Katherine A. ;

Hornung, Veit .

NATURE IMMUNOLOGY, 2009, 10 (10) :1065-U40

[2] Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands [J].

Barbalat, Roman ;

Lau, Laura ;

Locksley, Richard M. ;

Barton, Gregory M. .

NATURE IMMUNOLOGY, 2009, 10 (11) :1200-U87

[3] A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling [J].

Bowie, A ;

Kiss-Toth, E ;

Symons, JA ;

Smith, GL ;

Dower, SK ;

O'Neill, LAJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10162-10167

[4] An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome [J].

Buerckstuemmer, Tilmann ;

Baumann, Christoph ;

Blueml, Stephan ;

Dixit, Evelyn ;

Duernberger, Gerhard ;

Jahn, Hannah ;

Planyavsky, Melanie ;

Bilban, Martin ;

Colinge, Jacques ;

Bennett, Keiryn L. ;

Superti-Furga, Giulio .

NATURE IMMUNOLOGY, 2009, 10 (03) :266-272

[5] Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells [J].

Cheng, Guofeng ;

Zhong, Jin ;

Chung, Josan ;

Chisari, Francis V. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (21) :9035-9040

[6] RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway [J].

Chiu, Yu-Hsin ;

MacMillan, John B. ;

Chen, Zhijian J. .

CELL, 2009, 138 (03) :576-591

[7] Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1 [J].

DeFilippis, Victor R. ;

Alvarado, David ;

Sali, Tina ;

Rothenburg, Stefan ;

Frueh, Klaus .

JOURNAL OF VIROLOGY, 2010, 84 (01) :585-598

[8] AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA [J].

Fernandes-Alnemri, Teresa ;

Yu, Je-Wook ;

Datta, Pinaki ;

Wu, Jianghong ;

Alnemri, Emad S. .

NATURE, 2009, 458 (7237) :509-U5

[9] Toll-like receptor signaling controls reactivation of KSHV from latency [J].

Gregory, Sean M. ;

West, John A. ;

Dillon, Patrick J. ;

Hilscher, Chelsey ;

Dittmer, Dirk P. ;

Damania, Blossom .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (28) :11725-11730

[10] The poxvirus protein A52R targets toll-like receptor signaling complexes to suppress host defense [J].

Harte, MT ;

Haga, IR ;

Maloney, G ;

Gray, P ;

Reading, PC ;

Bartlett, NW ;

Smith, GL ;

Bowie, A ;

O'Neill, LAJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (03) :343-351

← 1 2 3 4 5 →