Sensing and Signaling in Antiviral Innate Immunity

被引：159

作者：

O'Neill, Luke A. J. ^{[1
]}

Bowie, Andrew G. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Immunol Res Ctr, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

CURRENT BIOLOGY | 2010年 / 20卷 / 07期

基金：

爱尔兰科学基金会;

关键词：

DOUBLE-STRANDED-RNA; CYTOSOLIC DNA; 5'-TRIPHOSPHATE RNA; VACCINIA VIRUS; DAI DLM-1/ZBP1; I INTERFERON; RESPONSES; INFLAMMASOME; RECOGNITION; ACTIVATION;

D O I：

10.1016/j.cub.2010.01.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viruses are detected by the innate immune system, leading to the initiation of the anti-viral immune response via the production of type I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress has been made over the past few years towards understanding the contribution of Toll-like receptors, RIG-I like receptors, NOD-like receptors and HIN-200 family members to viral detection. Furthermore, new complexities in the signaling pathways activated by these receptors continue to be revealed. Together, these new insights are leading to therapeutically useful information in the fight against viruses. © 2010 Elsevier Ltd. All rights reserved.

引用

页码：R328 / R333

页数：6

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