Resistance to Linezolid in a Porcine Clostridium perfringens Strain Carrying a Mutation in the rplD Gene Encoding the Ribosomal Protein L4

被引:31
作者
Hoelzel, Christina S. [1 ]
Harms, Katrin S. [1 ]
Schwaiger, Karin [1 ]
Bauer, Johann [1 ]
机构
[1] Tech Univ Munich, Chair Anim Hyg, D-85354 Freising Weihenstephan, Germany
关键词
ANTIMICROBIAL RESISTANCE; CHLORAMPHENICOL; OXAZOLIDINONES; SUSCEPTIBILITY; PREVALENCE; RELEVANCE; BACTERIA;
D O I
10.1128/AAC.01208-09
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region of rplD, encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genus Clostridium.
引用
收藏
页码:1351 / 1353
页数:3
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