Resistance to Linezolid in a Porcine Clostridium perfringens Strain Carrying a Mutation in the rplD Gene Encoding the Ribosomal Protein L4

被引：31

作者：

Hoelzel, Christina S. ^{[1
]}

Harms, Katrin S. ^{[1
]}

Schwaiger, Karin ^{[1
]}

Bauer, Johann ^{[1
]}

机构：

[1] Tech Univ Munich, Chair Anim Hyg, D-85354 Freising Weihenstephan, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 03期

关键词：

ANTIMICROBIAL RESISTANCE; CHLORAMPHENICOL; OXAZOLIDINONES; SUSCEPTIBILITY; PREVALENCE; RELEVANCE; BACTERIA;

D O I：

10.1128/AAC.01208-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region of rplD, encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genus Clostridium.

引用

页码：1351 / 1353

页数：3

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