Palivizumab-Resistant Human Respiratory Syncytial Virus Infection in Infancy

被引：55

作者：

Adams, Ortwin ^{[1
]}

Bonzel, Linda ^{[1
]}

Kovacevic, Alexander ^{[2
]}

Mayatepek, Ertan ^{[2
]}

Hoehn, Thomas ^{[2
]}

Vogel, Markus ^{[2
]}

机构：

[1] Univ Dusseldorf, Univ Childrens Hosp, Inst Virol, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Univ Childrens Hosp, Dept Gen Pediat, D-40225 Dusseldorf, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2010年 / 51卷 / 02期

关键词：

OUTCOMES REGISTRY; F-GLYCOPROTEIN; COTTON RATS; MUTANTS; PROPHYLAXIS; VITRO;

D O I：

10.1086/653534

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Palivizumab-resistant respiratory syncytial virus was isolated from an infant treated with palivizumab. A stable mutation at codon 276 led to a nearly complete resistance to palivizumab. Additional studies revealed a second mutation at codon 272. Further passage of the virus led to a complete loss of binding of palivizumab.

引用

页码：185 / 188

页数：4

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