机构:
Western Penn Hosp, Dept Med, Pittsburgh, PA 15224 USA
Temple Univ, Sch Med, Philadelphia, PA 19122 USAWestern Penn Hosp, Dept Med, Pittsburgh, PA 15224 USA
Gradman, Alan H.
[1
,2
]
Basile, Jan N.
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ S Carolina, Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USAWestern Penn Hosp, Dept Med, Pittsburgh, PA 15224 USA
Basile, Jan N.
[3
]
Carter, Barry L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Roy J & Lucille A Carver Coll Med, Iowa City, IA USAWestern Penn Hosp, Dept Med, Pittsburgh, PA 15224 USA
Carter, Barry L.
[4
]
Bakris, George L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USAWestern Penn Hosp, Dept Med, Pittsburgh, PA 15224 USA
Bakris, George L.
[5
]
机构:
[1] Western Penn Hosp, Dept Med, Pittsburgh, PA 15224 USA
[2] Temple Univ, Sch Med, Philadelphia, PA 19122 USA
[3] Med Univ S Carolina, Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USA
[4] Univ Iowa, Roy J & Lucille A Carver Coll Med, Iowa City, IA USA
[5] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA
The goal of antihypertensive therapy is to abolish the risks associated with blood pressure (BP) elevation without adversely affecting quality of life. Drug selection is based on efficacy in lowering BP and in reducing cardiovascular (CV) end points including stroke, myocardial infarction, and heart failure. Although the choice of initial drug therapy exerts some effect on long-term outcomes, it is evident that BP reduction per se is the primary determinant of CV risk reduction. Available data suggest that at least 75% of patients will require combination therapy to achieve contemporary BP targets, and increasing emphasis is being placed on the practical tasks involved in consistently achieving and maintaining goal BP in clinical practice. It is within this context that the American Society of Hypertension presents this Position Paper on Combination Therapy for Hypertension. It will address the scientific basis of combination therapy, present the pharmacologic rationale for choosing specific drug combinations, and review patient selection criteria for initial and secondary use. The advantages and disadvantages of single pill (fixed) drug combinations, and the implications of recent clinical trials involving specific combination strategies will also be discussed. J Am Soc Hypertens 2010;4(1):42-50. (C) 2010 American Society of Hypertension. All rights reserved.
机构:
Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Univ Iowa, Roy J & Lucille A Carver Coll Publ Hlth, Dept Family Med, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Carter, Barry L.
Bergus, George R.
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机构:
Univ Iowa, Roy J & Lucille A Carver Coll Publ Hlth, Dept Family Med, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Bergus, George R.
Dawson, Jeffrey D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Biostat, Coll Publ Hlth, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Dawson, Jeffrey D.
Farris, Karen B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Farris, Karen B.
Doucette, William R.
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h-index: 0
机构:
Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Doucette, William R.
Chrischilles, Elizabeth A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Chrischilles, Elizabeth A.
Hartz, Arthur J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Roy J & Lucille A Carver Coll Publ Hlth, Dept Family Med, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
机构:
Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Univ Iowa, Roy J & Lucille A Carver Coll Publ Hlth, Dept Family Med, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Carter, Barry L.
Bergus, George R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Roy J & Lucille A Carver Coll Publ Hlth, Dept Family Med, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Bergus, George R.
Dawson, Jeffrey D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Biostat, Coll Publ Hlth, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Dawson, Jeffrey D.
Farris, Karen B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Farris, Karen B.
Doucette, William R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Doucette, William R.
Chrischilles, Elizabeth A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA
Chrischilles, Elizabeth A.
Hartz, Arthur J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Iowa, Roy J & Lucille A Carver Coll Publ Hlth, Dept Family Med, Iowa City, IA 52242 USAUniv Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA