Covariance mapping in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

被引：12

作者：

Feldman, AB ^{[1
]}

Antoine, M ^{[1
]}

Lin, JS ^{[1
]}

Demirev, PA ^{[1
]}

机构：

[1] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2003年 / 17卷 / 09期

关键词：

D O I：

10.1002/rcm.1013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel method for acquisition and numerical analysis of matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectral data is described. The digitized ion current transient from each consecutive laser shot is first acquired and stored independently. Subsequently, statistical correlation. parameters between all stored transients are computed. We illustrate the uses of this event-by-event analysis method for studies of sample surface heterogeneity as well as for elucidating the mechanisms of ion formation in MALDI. Other potential applications of the method are also outlined. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：991 / 995

页数：5

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