Organometallic photonucleases: Synthesis and DNA-cleavage studies of cyclopentadienyl metal-substituted dendrimers designed to increase double-strand scission

被引：34

作者：

Hurley, AL ^{[1
]}

Mohler, DL ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 18期

关键词：

D O I：

10.1021/ol006030o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of metal complex-substituted polyamine dendrimers have been synthesized and examined for their ability to cleave plasmid DNA in a double-stranded manner. While photolysis of the dimetallic spermine derivative and the tetrametallic DAB-Am-4 complex led to double-strand scission, in the larger DAB-Am-8 and DAB-Am-16 systems, DNA aggregation/precipitation was the predominant competing process observed.

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页码：2745 / 2748

页数：4

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