A simple synthetic approach to homochiral 6-and 6′-substituted 1,1′-binaphthyl derivatives

被引：71

作者：

Hocke, H ^{[1
]}

Uozumi, Y ^{[1
]}

机构：

[1] Inst Mol Sci, Okazaki, Aichi 4448585, Japan

来源：

TETRAHEDRON | 2003年 / 59卷 / 05期

基金：

日本学术振兴会;

关键词：

1,1 '-binaphthyls; immobilization; polymer-supports;

D O I：

10.1016/S0040-4020(02)01584-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various homochiral binaphthyl derivatives having functional groups at the 6-position are important key intermediates for the immobilization of binaphthyl compounds on various solid-supports and have been prepared from commercially available 1,1'-bi-2-naphthol via controlled monopivalation of the 2-hydroxyl group and electrophilic aromatic substitution at the 6-position. (S)-2,2'-Bis-((S)-4-alkyloxazol-2-yl)-6-(2-methoxycarbonyl)ethyl-1,1'-binaphthyls (6-functionalized (S,S)-boxax)) were prepared and immobilized on various polymer supports including PS-PEG, PS, PEGA and MeO-PEG resin. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：619 / 630

页数：12

共 38 条

[1] Enantioselective catalytic conjugate addition of dialkylzinc reagents using copper-phosphoramidite complexes; Ligand variation and non-linear effects [J].