Magnetic resonance cerebral metabolic rate of oxygen utilization in hyperacute stroke patients

被引:92
作者
Lee, JM
Vo, KD
An, HY
Celik, A
Lee, Y
Hsu, CY
Lin, WL
机构
[1] Univ N Carolina, Dept Radiol & Biomed Engn, Chapel Hill, NC 27599 USA
[2] Washington Univ, Dept Neurol, St Louis, MO 63130 USA
[3] Washington Univ, Dept Radiol, St Louis, MO 63130 USA
[4] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA
关键词
D O I
10.1002/ana.10433
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The purpose of this study was to explore the feasibility of obtaining magnetic resonance-measured cerebral metabolic rate of oxygen utilization (MR-CMRO2) in acute ischemic stroke patients. Seven stroke patients were serially imaged: 4.5 +/- 0.9 hours (tp1), 3 to 5 days (tp2), and I to 3 months (tp3) after symptom onset. Diffusion-weighted, perfusion-weighted, and multiecho gradient-echo/spin-echo images were acquired; cerebral blood flow and oxygen extraction fraction maps were obtained from which CMRO2 was calculated as the product of cerebral blood flow and oxygen extraction fraction. The final infarct lesions obtained from tp3 T2-weighted images and the "penumbra" obtained from the tp1 perfusion-weighted image-defined lesion were coregistered onto tp1 CMRO2 maps. CMRO2 values in the region of brain that eventually infarcted were reduced to 0.40 +/- 0.24 of the respective region on the contralateral hemisphere. The "salvaged penumbra" defined by the area of mismatch between the final infarct and the tp1 perfusion-weighted lesion demonstrated an average CMRO2 value of 0.55 +/- 0.11 of the contralateral hemisphere. Although our results are preliminary and require further evaluation, the ability to obtain in vivo measurements of MR-CMRO2 noninvasively potentially can provide information for determining brain tissue viability in acute ischemic stroke patients.
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页码:227 / 232
页数:6
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