Electrospinning of nanofiber fibrinogen structures

被引：439

作者：

Wnek, GE

Carr, ME

Simpson, DG

Bowlin, GL

机构：

[1] Virginia Commonwealth Univ, Dept Biomed Engn, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Dept Chem Engn, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Dept Internal Med Hematol & Oncol, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA 23298 USA

来源：

NANO LETTERS | 2003年 / 3卷 / 02期

关键词：

D O I：

10.1021/nl025866c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first results of electrospinning fibrinogen nanofibers for use as a tissue-engineering scaffold, wound dressing, or hemostatic bandage are reported. Structures composed of fibrinogen fibers with an average diameter of 80-700 nm were electrospun from solutions composed of human or bovine fibrinogen fraction I dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol and minimal essential medium (Earle's salts). In summary, the electrospinning process is a simple and efficient technique for the fabrication of 3D structures composed of fibrinogen fibers, as would be present in the physiologic environment.

引用

页码：213 / 216

页数：4

共 25 条

[21] A biomechanical analysis of an engineered cell-scaffold implant for cartilage repair [J].