Synthesis of bicyclic azacompounds (3-dimethylecarbamoyl-oxyphenyl) substituted as acetylcholinesterase inhibitors

This paper describes the synthesis of some bicyclic 2-(3-dimethylcarbamoyloxyphenyl) substituted azaderivatives, obtained from 1,4- and 1,5-diketones, which were cyclized with ammonium acetate, methylamine and by reductive amination. Corresponding 3-substituted derivatives were instead prepared by reaction of 1,5-ketoesters with formamide. The carbamates were tested as in vitro acetylcholinesterase inhibitors.