Microwave-assisted synthesis of O′-adamantylated uracil-derived nucleosides

被引：5

作者：

Górska, A

Andrzejewska, M

Kaminski, J

Kazimierczuk, Z

机构：

[1] Univ Agr, Inst Chem, PL-02787 Warsaw, Poland

[2] Polish Acad Sci, Med Res Ctr, Lab Expt Pharmacol, PL-02106 Warsaw, Poland

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 01期

关键词：

microwave irradiation; O '-adamantylation; solvent-free reactions; AZT; thymidine; 2 '-deoxyuridine;

D O I：

10.1081/NCN-120018620

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microwave-induced synthesis of O'-adamantyl derivatives of AZT, thymidine, 2'-deoxyuridine and uridine was investigated. Contrary to heterocyclus adamantylation of uracil and uridine in trifluoroacetic acid, the microwave-induced reaction provided sugar-substituted compounds.

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页码：13 / 19

页数：7

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