"CRASH"ing With the Worm: Insights Into L1CAM Functions and Mechanisms

被引：24

作者：

Chen, Lihsia ^{[1
]}

Zhou, Shan ^{[1
]}

机构：

[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Ctr Dev Biol, Minneapolis, MN 55455 USA

来源：

DEVELOPMENTAL DYNAMICS | 2010年 / 239卷 / 05期

关键词：

L1CAMs; C; elegans; lad-2; sax-7; axon guidance; neural maintenance; NEURAL-CELL-ADHESION; DUCHENNE MUSCULAR-DYSTROPHY; X-LINKED HYDROCEPHALUS; PERIPHERAL NERVOUS-SYSTEM; L1 KNOCKOUT MICE; CAENORHABDITIS-ELEGANS; MOLECULE L1; CLOSE HOMOLOG; CYTOPLASMIC DOMAIN; NEURITE OUTGROWTH;

D O I：

10.1002/dvdy.22269

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The L1 family of cell adhesion molecules (L1CAMs) in vertebrates has long been studied for its roles in nervous system development and function. Members of this family have been associated with distinct neurological disorders that include CRASH, autism, 3p syndrome, and schizophrenia. The conservation of L1CAMs in Drosophila and Caenorhabditis elegans allows the opportunity to take advantage of these simple model organisms and their accessible genetic manipulations to dissect L1CAM functions and mechanisms of action. This review summarizes the discoveries of L1CAMs made in C. elegans, showcasing this simple model organism as a powerful system to uncover L1CAM mechanisms and roles in healthy and diseased states. Developmental Dynamics 239:1490-1501, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：1490 / 1501

页数：12

共 128 条

[91] The plexin PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/semaphorin 2A signaling in Caenorhabditis elegans morphogenesis [J].

Nakao, Fumi ;

Hudson, Martin L. ;

Suzuki, Motoshi ;

Peckler, Zachary ;

Kurokawa, Rie ;

Liu, Zhicen ;

Gengyo-Ando, Keiko ;

Nukazuka, Akira ;

Fujii, Takashi ;

Suto, Fumikazu ;

Shibata, Yukimasa ;

Shioi, Go ;

Fujisawa, Hajime ;

Mitani, Shohei ;

Chisholm, Andrew D. ;

Takagi, Shin .

GENETICS, 2007, 176 (03) :1591-1607

[92] Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death [J].

Naus, S ;

Richter, M ;

Wildeboer, D ;

Moss, M ;

Schachner, M ;

Bartsch, JW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (16) :16083-16090

[93]

Nayeem N, 1999, J CELL SCI, V112, P4739

[94] Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions [J].

Needham, LK ;

Thelen, K ;

Maness, PF .

JOURNAL OF NEUROSCIENCE, 2001, 21 (05) :1490-1500

[95] Syntrophin γ2 regulates SCN5A Gating by a PDZ domain-mediated interaction [J].

Ou, YJ ;

Strege, P ;

Miller, SM ;

Makielski, J ;

Ackerman, M ;

Gibbons, SJ ;

Farrugia, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1915-1923

[96] DYSTROPHIN PROTECTS THE SARCOLEMMA FROM STRESSES DEVELOPED DURING MUSCLE-CONTRACTION [J].

PETROF, BJ ;

SHRAGER, JB ;

STEDMAN, HH ;

KELLY, AM ;

SWEENEY, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3710-3714

[97] γ1-and γ2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells [J].

Piluso, G ;

Mirabella, M ;

Ricci, E ;

Belsito, A ;

Abbondanza, C ;

Servidei, S ;

Puca, AA ;

Tonali, P ;

Puca, GA ;

Nigro, V .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (21) :15851-15860

[98] Functional dissection of the C-elegans cell adhesion molecule SAX-7, a homologue of human L1 [J].

Pocock, Roger ;

Nard, Claire Y. ;

Shapiro, Lawrence ;

Hobert, Oliver .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2008, 37 (01) :56-68

[99] Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization [J].

Putnam, Nicholas H. ;

Srivastava, Mansi ;

Hellsten, Uffe ;

Dirks, Bill ;

Chapman, Jarrod ;

Salamov, Asaf ;

Terry, Astrid ;

Shapiro, Harris ;

Lindquist, Erika ;

Kapitonov, Vladimir V. ;

Jurka, Jerzy ;

Genikhovich, Grigory ;

Grigoriev, Igor V. ;

Lucas, Susan M. ;

Steele, Robert E. ;

Finnerty, John R. ;

Technau, Ulrich ;

Martindale, Mark Q. ;

Rokhsar, Daniel S. .

SCIENCE, 2007, 317 (5834) :86-94

[100]

RAND JB, 1985, PSYCHOPHARMACOL BULL, V21, P623

← 4 5 6 7 8 9 10 11 12 13 →