Radiation esophagitis: Predictive factors and preventive strategies

被引:39
作者
Bradley, J
Movsas, B
机构
[1] Washington Univ, Sch Med, Dept Radiat Oncol, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA
[2] Fox Chase Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19111 USA
关键词
D O I
10.1016/j.semradonc.2004.06.003
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation esophagitis remains the primary dose-limiting acute toxicity in the radiotherapeutic management of thoracic neoplasms. Improved understanding of this toxicity will facilitate dose escalation and enhancement of the therapeutic ratio. This article reviews the predictive factors and preventive strategies for radiation esophagitis. In particular, clinical and dosimetric studies predicting the risk of radiation esophagitis are analyzed. The critical impact of chemotherapy on radiation esophagitis is characterized. Preventive strategies to minimize this toxicity also are explored. Overall, this article reviews the current understanding of radiation toxicity for the esophagus. © 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:280 / 286
页数:7
相关论文
共 28 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]   Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non-small-cell lung cancer [J].
Antonadou, D ;
Throuvalas, N ;
Petridis, A ;
Bolanos, N ;
Sagriotis, A ;
Synodinou, M .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 57 (02) :402-408
[3]   Randomized phase III trial of radiation treatment ± amifostine in patients with advanced-stage lung cancer [J].
Antonadou, D ;
Coliarakis, N ;
Synodinou, M ;
Athanassiou, H ;
Kouveli, A ;
Verigos, C ;
Georgakopoulos, G ;
Panoussaki, K ;
Karageorgis, P ;
Throuvalas, N .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (04) :915-922
[4]   THE EORTC QLQ-LC13 - A MODULAR SUPPLEMENT TO THE EORTC CORE QUALITY-OF-LIFE QUESTIONNAIRE (QLQ-C30) FOR USE IN LUNG-CANCER CLINICAL-TRIALS [J].
BERGMAN, B ;
AARONSON, NK ;
AHMEDZAI, S ;
KAASA, S ;
SULLIVAN, M .
EUROPEAN JOURNAL OF CANCER, 1994, 30A (05) :635-642
[5]   Dosimetric correlates for acute esophagitis in patients treated with radiotherapy for lung carcinoma [J].
Bradley, J ;
Deasy, JO ;
Bentzen, S ;
El Naqa, I .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 58 (04) :1106-1113
[6]   Response, toxicity, failure patterns, and survival in five radiation therapy oncology group (RTOG) trials of sequential and/or concurrent chemotherapy and radiotherapy for locally advanced non-small-cell carcinoma of the lung [J].
Byhardt, RW ;
Scott, C ;
Sause, WT ;
Emami, B ;
Komaki, R ;
Fisher, B ;
Lee, JS ;
Lawton, C .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 42 (03) :469-478
[7]   ALKALINE-PHOSPHATASE PROMOTES RADIOPROTECTION AND ACCUMULATION OF WR-1065 IN V79-171 CELLS INCUBATED IN MEDIUM CONTAINING WR-2721 [J].
CALABROJONES, PM ;
FAHEY, RC ;
SMOLUK, GD ;
WARD, JF .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1985, 47 (01) :23-27
[8]   Multiinstitutional phase II trial of paclitaxel, carboplatin, and concurrent radiation therapy for locally advanced non-small-cell lung cancer [J].
Choy, H ;
Akerley, W ;
Safran, H ;
Graziano, S ;
Chung, C ;
Williams, T ;
Cole, B ;
Kennedy, T .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (10) :3316-3322
[9]   A RANDOMIZED TRIAL OF INDUCTION CHEMOTHERAPY PLUS HIGH-DOSE RADIATION VERSUS RADIATION ALONE IN STAGE-III NON-SMALL-CELL LUNG-CANCER [J].
DILLMAN, RO ;
SEAGREN, SL ;
PROPERT, KJ ;
GUERRA, J ;
EATON, WL ;
PERRY, MC ;
CAREY, RW ;
FREI, EF ;
GREEN, MR .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (14) :940-945
[10]   TOLERANCE OF NORMAL TISSUE TO THERAPEUTIC IRRADIATION [J].
EMAMI, B ;
LYMAN, J ;
BROWN, A ;
COIA, L ;
GOITEIN, M ;
MUNZENRIDER, JE ;
SHANK, B ;
SOLIN, LJ ;
WESSON, M .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 21 (01) :109-122