Stopping Ras in its tracks

被引：26

作者：

Der, Channing J. ^{[1
]}

Van Dyke, Terry

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pharmacol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA

来源：

CELL | 2007年 / 129卷 / 05期

关键词：

D O I：

10.1016/j.cell.2007.05.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

引用

收藏

页码：855 / 857

页数：3

相关论文

共 10 条

[1]

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma [J].

Aguirre, AJ ;

Bardeesy, N ;

Sinha, M ;

Lopez, L ;

Tuveson, DA ;

Horner, J ;

Redston, MS ;

DePinho, RA .

GENES & DEVELOPMENT, 2003, 17 (24) :3112-3126

[2]

Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[3]

Gupta S, 2007, CELL

[4]

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse [J].

Hingorani, SR ;

Petricoin, EF ;

Maitra, A ;

Rajapakse, V ;

King, C ;

Jacobetz, MA ;

Ross, S ;

Conrads, TP ;

Veenstra, TD ;

Hitt, BA ;

Kawaguchi, Y ;

Johann, D ;

Liotta, LA ;

Crawford, HC ;

Putt, ME ;

Jacks, T ;

Wright, CVE ;

Hruban, RH ;

Lowy, AM ;

Tuveson, DA .

CANCER CELL, 2003, 4 (06) :437-450

[5]

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice [J].

Johnson, L ;

Mercer, K ;

Greenbaum, D ;

Bronson, RT ;

Crowley, D ;

Tuveson, DA ;

Jacks, T .

NATURE, 2001, 410 (6832) :1111-1116

[6]

Lim KH, 2005, CANCER CELL, V8, P381, DOI 10.1016/j.ccr.2005.10.014

[7]

Activation of RaIA is critical for Ras-induced tumorigenesis of human cells [J].

Lim, KH ;

Baines, AT ;

Fiordalisi, JJ ;

Shipitsin, M ;

Feig, LA ;

Cox, AD ;

Der, CJ ;

Counter, CM .

CANCER CELL, 2005, 7 (06) :533-545

[8]

Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? [J].

Repasky, GA ;

Chenette, EJ ;

Der, CJ .

TRENDS IN CELL BIOLOGY, 2004, 14 (11) :639-647

[9]

Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate [J].

Rodriguez-Viciana, P ;

Sabatier, C ;

McCormick, F .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (11) :4943-4954

[10]

High frequency of mutations of the PIK3CA gene in human cancers [J].

Samuels, Y ;

Wang, ZH ;

Bardelli, A ;

Silliman, N ;

Ptak, J ;

Szabo, S ;

Yan, H ;

Gazdar, A ;

Powell, DM ;

Riggins, GJ ;

Willson, JKV ;

Markowitz, S ;

Kinzler, KW ;

Vogelstein, B ;

Velculescu, VE .

SCIENCE, 2004, 304 (5670) :554-554