Evaluation of dynamic image progression of minimally invasive and preinvasive lung adenocarcinomas

被引：4

作者：

Chen, Tianxiang ^{[1
]}

Zhang, Xiaocheng ^{[2
]}

Campisi, Alessio ^{[1
,3
]}

Ciarrocchi, Angelo Paolo ^{[3
]}

Dell'Amore, Andrea ^{[4
]}

Song, Liwei ^{[1
]}

Yang, Yunhai ^{[1
]}

Chen, Chengshui ^{[2
]}

Luo, Qingquan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai Lung Canc Ctr, 241 Huai Hai Rd, Shanghai 200030, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Pulm Med, Wenzhou 325000, Peoples R China

[3] Univ Bologna, Dept Thorac Dis, Thorac Surg Unit, GB Morgagni L Pierantoni Hosp, Forli, Italy

[4] Univ Padua, Padua Univ Hosp, Dept Cardiothorac Surg & Vasc Sci, Div Thorac Surg, Padua, Italy

来源：

ANNALS OF TRANSLATIONAL MEDICINE | 2021年 / 9卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Ground-glass opacities (GGOs); size; adenocarcinoma in situ (AIS); minimally invasive adenocarcinoma (MIA); progression; follow-up; GROUND-GLASS OPACITY; THIN-SECTION CT; IN-SITU; INTERNATIONAL ASSOCIATION; INTEROBSERVER-AGREEMENT; TUMOR SIZE; CLASSIFICATION; GROWTH; CANCER; MUTATIONS;

D O I：

10.21037/atm-21-1994

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: The target of our study was to investigate if the size (greater than and less than 1 cm) of ground-glass opacities (GGOs) of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) of the lung influences the rate of their evolution. Methods: We retrospectively analyzed patients with AIS and MIA who underwent surgery at Shanghai Chest Hospital, Shanghai Jiao Tong University between January 2018 and July 2019, focusing on histopathology, surgical procedure, epidermal growth factor receptor (EGFR) mutations, and computed tomography (CT) images. Results: A total of 224 AIS (n=117) and MIA (n=107) tumors were analyzed. The patients with a tumor diameter <1 cm were distinctly younger than those with tumors >1 cm in size (P<0.001). Pure ground glass opacities (pGGO) occurred significantly more in patients with nodules <1 cm, while part-solid/ mixed ground-glass opacities (mGGO) predominated in patients with nodules >1 cm (P=0.047). There was no significant difference in GGO evolution for GGOs of different sizes. Mutations of EGFR were more common in patients with MIA than in those with AIS (P<0.001). Conclusions: We found that GGO size and variation (pGGO or mGGO) did not correlate to tumor stability, therefore larger GGOs can undergo standard follow-up protocols to evaluate their evolution over time.

引用

页数：10

共 28 条

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