Association of the ABCB1 3435C>T polymorphism and treatment outcomes in advanced gastric cancer patients treated with paclitaxel-based chemotherapy

被引：34

作者：

Chang, Hyun ^{[2
,3
]}

Rha, Sun Young ^{[2
,3
]}

Jeung, Hei-Cheul ^{[2
,3
]}

Im, Chong Kun ^{[2
,3
]}

Noh, Sung Hoon ^{[2
,3
,4
]}

Kim, Jin Ju ^{[5
]}

Chung, Hyun Cheol ^{[1
,2
,3
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Canc Metastasis Res Ctr,Yonsei Canc Ctr,Div Med O, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Canc Metastasis Res Ctr, Seoul 120752, South Korea

[3] Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea

[4] Yonsei Univ, Coll Med, Dept Surg, Seoul 120752, South Korea

[5] Inha Univ, Sch Med, Dept Lab Med, Inchon, South Korea

来源：

ONCOLOGY REPORTS | 2010年 / 23卷 / 01期

关键词：

ABCB1; polymorphism; stomach cancer; paclitaxel; clinical outcome; P-GLYCOPROTEIN EXPRESSION; LOW-DOSE LEUCOVORIN; BREAST-CANCER; MDR1; GENE; INFUSIONAL; 5-FLUOROURACIL; PHASE-II; RESISTANCE; HAPLOTYPES; DOCETAXEL; TRANSPORT;

D O I：

10.3892/or_00000633

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluated the frequency of ABCB1 polymorphisms (2677G/T>A and 3435C>T) and Studied the association between the polymorphisms and clinical outcomes of paclitaxel-based chemotherapy in advanced gastric cancer patients. This study was performed in 43 gastric cancer patients and a control group consisting of 118 healthy Volunteers. Patients were treated with paclitaxel combined with ail infusional 5-fluorouracil and low-dose leucovorin. Genomic DNA from peripheral blood mononuclear cells was used to determine ABCB1 polymorphisms by direct sequencing. Genotypes were investigated for their association with survival and toxicity. The ABCB1 3435 C allele was more frequent in gastric cancer patients than healthy volunteers (p<0.001). The 2677G>T/A and 3435C>T polymorphisms were independent factors associated with shorter progression-free survival (PFS) (1)=0.024, p=0.001, respectively). In combined analysis of 2677 and 3435 polymorphisms, the 3435C>T polymorphism was an independent factor for poor PFS (p=0.01). The 3435CT and TT genotypes were associated with mucositis (p=0.04), and the variant genotypes at 2677 loci were associated with diarrhea (p=0.034). Our data suggest that the ABCB1 polymorphism at 3435 is associated with clinical Outcomes after paclitaxel-based combined chemotherapy in advanced gastric cancer patients.

引用

页码：271 / 278

页数：8

共 30 条

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