Catalytic antibodies

被引:53
作者
Wentworth, P
Janda, KD
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1016/S1367-5931(98)80046-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Following the end of the first decade in catalytic antibody research, recent efforts are reflecting a more introspective view of the field. Notably, X-ray crystal structure analyses of antibody catalysts are permitting an increased understanding of the evolution and modus operandi of these remarkable biocatalysts. Additionally, the breadth and scope of new antibody-catalyzed reactions and novel hapten design strategies have continued to flourish with support from an increasing number of contributors to this ever expanding area.
引用
收藏
页码:138 / 144
页数:7
相关论文
共 35 条
[1]   A nitroxyl synthase catalytic antibody [J].
Bahr, N ;
Guller, R ;
Reymond, JL ;
Lerner, RA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (15) :3550-3555
[2]   anti-sulfonamide antibodies catalyse the hydrolysis of a heterocyclic amide [J].
Benedetti, F ;
Berti, F ;
Colombatti, A ;
Ebert, C ;
Linda, P ;
Tonizzo, F .
CHEMICAL COMMUNICATIONS, 1996, (12) :1417-1418
[3]   Copying nature's mechanism for the decarboxylation of beta-keto acids into catalytic antibodies by reactive immunization [J].
Bjornestedt, R ;
Zhong, GF ;
Lerner, RA ;
Barbas, CF .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (47) :11720-11724
[4]  
BLACKBURN GM, 1997, IN PRESS ADV PHYS OR
[5]   ANTIBODY-CATALYZED PRODRUG ACTIVATION [J].
CAMPBELL, DA ;
GONG, B ;
KOCHERSPERGER, LM ;
YONKOVICH, S ;
GALLOP, MA ;
SCHULTZ, PG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (05) :2165-2166
[6]   Structural convergence in the active sites of a family of catalytic antibodies [J].
Charbonnier, JB ;
GolinelliPimpaneau, B ;
Gigant, B ;
Tawfik, DS ;
Chap, R ;
Schindler, DG ;
Kim, SH ;
Green, BS ;
Eshhar, Z ;
Knossow, M .
SCIENCE, 1997, 275 (5303) :1140-1142
[7]   Antibody-catalyzed retro-aldol reaction [J].
Flanagan, ME ;
Jacobsen, JR ;
Sweet, E ;
Schultz, PG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (25) :6078-6079
[8]   Formation of bridge-methylated decalins by antibody-catalyzed tandem cationic cyclization [J].
Hasserodt, J ;
Janda, KD ;
Lerner, RA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (26) :5993-5998
[9]   Chemical selection for catalysis in combinatorial antibody libraries [J].
Janda, KD ;
Lo, LC ;
Lo, CHL ;
Sim, MM ;
Wang, R ;
Wong, CH ;
Lerner, RA .
SCIENCE, 1997, 275 (5302) :945-948
[10]  
JANDA KD, 1996, COMPREHENSIVE SUPRAM, P43