Cardiac xenotransplantation: Clinical experience and future direction

被引：13

作者：

Adams, DH ^{[1
]}

Chen, RH ^{[1
]}

Kadner, A ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiac Surg, Boston, MA 02115 USA

来源：

ANNALS OF THORACIC SURGERY | 2000年 / 70卷 / 01期

关键词：

D O I：

10.1016/S0003-4975(00)01281-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The shortage of human organs has focused research on finding an animal source of replacement organs. The immunological barriers to xenotransplantation are now more clearly defined, allowing retrospective interpretation of past clinical experience in humans. Due to physiological compatibilities as well as ethical and infectious considerations, pigs have now emerged as the most likely source of future xenografts. The introduction of transgenic pigs expressing human complement regulatory proteins and new immunosuppressive regimens have shown early promise in the laboratory, although further advancements are needed to advance to clinical trials. Additional clarification of infectious risks and patient strategies are remaining obstacles to application in the clinical arena. (Ann Thorac Surg 2000;70:320-6) (C) 2000 by The Society of Thoracic Surgeons.

引用

页码：320 / 326

页数：7

共 66 条

[21]

Fishman Jay A., 1994, Xenotransplantation, V1, P47, DOI 10.1111/j.1399-3089.1994.tb00049.x

[22]

FRIES JWU, 1993, AM J PATHOL, V143, P725

[23] EVOLUTIONARY RELATIONSHIP BETWEEN THE NATURAL ANTI-GAL ANTIBODY AND THE GAL-ALPHA-1-]3GAL EPITOPE IN PRIMATES [J].

GALILI, U ;

CLARK, MR ;

SHOHET, SB ;

BUEHLER, J ;

MACHER, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) :1369-1373

[24] Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes [J].

Gao, F ;

Bailes, E ;

Robertson, DL ;

Chen, YL ;

Rodenburg, CM ;

Michael, SF ;

Cummins, LB ;

Arthur, LO ;

Peeters, M ;

Shaw, GM ;

Sharp, PM ;

Hahn, BH .

NATURE, 1999, 397 (6718) :436-441

[25] HOMOLOGOUS SPECIES RESTRICTION IN LYSIS OF ERYTHROCYTES BY TERMINAL COMPLEMENT PROTEINS [J].

HANSCH, GM ;

HAMMER, CH ;

VANGURI, P ;

SHIN, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (08) :5118-5121

[26]

HARDY JD, 1969, TRANSPL P, V1, P717

[27]

Heneine W, 1998, LANCET, V352, P1478

[28] No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts [J].

Heneine, W ;

Tibell, A ;

Switzer, WM ;

Sandstrom, P ;

Rosales, GV ;

Mathews, A ;

Korsgren, O ;

Chapman, LE ;

Folks, TM ;

Groth, CG .

LANCET, 1998, 352 (9129) :695-699

[29]

Hosenpud JD, 1998, J HEART LUNG TRANSPL, V17, P656

[30]

INVERARDI L, 1992, J IMMUNOL, V149, P1416

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