Regulation of autophagy by phosphatidylinositol 3-phosphate

被引：179

作者：

Burman, Chloe ^{[1
]}

Ktistakis, Nicholas T. ^{[1
]}

机构：

[1] Babraham Inst, Signalling Programme, Cambridge CB22 3AT, England

来源：

FEBS LETTERS | 2010年 / 584卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Autophagy; Phosphoinositide; Signalling; Endoplasmic reticulum; PI; 3-Kinase; PROTEIN-KINASE; TUMOR-SUPPRESSOR; PHOSPHOINOSITIDE; 3-KINASE; SIGNALING PATHWAYS; VESICLE FORMATION; DISTINCT CLASSES; LIPID PRODUCTS; RAG GTPASES; HUMAN VPS34; PX-DOMAIN;

D O I：

10.1016/j.febslet.2010.01.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The simple phosphoinositide phosphatidylinositol 3-phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events. In autophagy, PI(3)P may form the platform for autophagosome biogenesis. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1302 / 1312

页数：11

共 114 条

[1] A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate [J].

Ano, Y ;

Hattori, T ;

Oku, M ;

Mukaiyama, H ;

Baba, M ;

Ohsumi, Y ;

Kato, N ;

Sakai, Y .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (02) :446-457

[2] Role for Rab5 in structuring the endoplasmic reticulum (vol 178, pg 43, 2007) [J].

Audhya, Anjon ;

Desai, Arshad ;

Oegema, Karen .

JOURNAL OF CELL BIOLOGY, 2007, 178 (07) :1309-1309

[3] Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].

Axe, Elizabeth L. ;

Walker, Simon A. ;

Manifava, Maria ;

Chandra, Priya ;

Roderick, H. Llewelyn ;

Habermann, Anja ;

Griffiths, Gareth ;

Ktistakis, Nicholas T. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701

[4] The regulation and function of Class III PI3Ks: novel roles for Vps34 [J].

Backer, Jonathan M. .

BIOCHEMICAL JOURNAL, 2008, 410 (01) :1-17

[5] Calcium signalling: Dynamics, homeostasis and remodelling [J].

Berridge, MJ ;

Bootman, MD ;

Roderick, HL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529

[6] The Vam6 GEF Controls TORC1 by Activating the EGO Complex [J].

Binda, Matteo ;

Peli-Gulli, Marie-Pierre ;

Bonfils, Gregory ;

Panchaud, Nicolas ;

Urban, Joerg ;

Sturgill, Thomas W. ;

Loewith, Robbie ;

De Virgilio, Claudio .

MOLECULAR CELL, 2009, 35 (05) :563-573

[7] The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes [J].

Blommaart, EFC ;

Krause, U ;

Schellens, JPM ;

VreelingSindelarova, H ;

Meijer, AJ .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 243 (1-2) :240-246

[8] PHOSPHORYLATION OF RIBOSOMAL-PROTEIN S6 IS INHIBITORY FOR AUTOPHAGY IN ISOLATED RAT HEPATOCYTES [J].

BLOMMAART, EFC ;

LUIKEN, JJFP ;

BLOMMAART, PJE ;

VANWOERKOM, GM ;

MEIJER, AJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (05) :2320-2326

[9] The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores [J].

Brady, Nathan R. ;

Hamacher-Brady, Anne ;

Yuan, Hua ;

Gottlieb, Roberta A. .

FEBS JOURNAL, 2007, 274 (12) :3184-3197

[10] Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains [J].

Burd, CG ;

Emr, SD .

MOLECULAR CELL, 1998, 2 (01) :157-162

← 1 2 3 4 5 6 7 8 9 10 →