Regulation of autophagy by phosphatidylinositol 3-phosphate

被引：179

作者：

Burman, Chloe ^{[1
]}

Ktistakis, Nicholas T. ^{[1
]}

机构：

[1] Babraham Inst, Signalling Programme, Cambridge CB22 3AT, England

来源：

FEBS LETTERS | 2010年 / 584卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Autophagy; Phosphoinositide; Signalling; Endoplasmic reticulum; PI; 3-Kinase; PROTEIN-KINASE; TUMOR-SUPPRESSOR; PHOSPHOINOSITIDE; 3-KINASE; SIGNALING PATHWAYS; VESICLE FORMATION; DISTINCT CLASSES; LIPID PRODUCTS; RAG GTPASES; HUMAN VPS34; PX-DOMAIN;

D O I：

10.1016/j.febslet.2010.01.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The simple phosphoinositide phosphatidylinositol 3-phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events. In autophagy, PI(3)P may form the platform for autophagosome biogenesis. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1302 / 1312

页数：11

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