Performance evaluation of the microPET R4 PET scanner for rodents

被引:208
作者
Knoess, C
Siegel, S
Smith, A
Newport, D
Richerzhagen, R
Winkeler, A
Jacobs, A
Goble, RN
Graf, R
Wienhard, K
Heiss, WD
机构
[1] Max Planck Inst Neurol Res, D-50931 Cologne, Germany
[2] Concorde Microsyst Inc, Knoxville, TN USA
[3] Ctr Mol Med, Cologne, Germany
[4] Univ Cologne, Dept Neurol, D-5000 Cologne 41, Germany
关键词
microPET; PET; performance evaluation; molecular imaging; small animal imaging;
D O I
10.1007/s00259-002-1052-6
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The microPET R4 scanner is a dedicated positron emission tomograph (PET) for studies of rodents. A number of scanner parameters such as spatial resolution, sensitivity, scatter, and count rate performance were determined in this work, which showed that the microPET R4 is a suitable PET scanner for small animals like mice and rats. In the center of the field of view (FOV) a maximal sensitivity of 43.66 cps/kBq for a centered point source was calculated from a measurement with a germanium-68 line source within an energy widow of 250-750 keV. A spatial resolution of 1.85 mm full-width at half-maximum (FWHM) in the axial direction and 1.66 mm FWHM in the transaxial direction was measured in the center with a 1-mm-diameter sodium-22 point source. Within the inner 20 mm of the FOV the volumetric resolution is better than 15.6 mul, corresponding to a linear resolution of less than 2.5 mm in all three dimensions. Images of a high-resolution phantom and from mice and rat studies illustrate the good performance of the scanner. A maximal noise equivalent count rate (NECR) was reached at 174 kcps for a mouse phantom and at 93 kcps for a rat phantom (energy window 250-750 keV). Scatter fractions were measured between 0.30 and 0.42 for an energy window of 250-750 keV and phantom diameters similar to mice and rats. A comparison with the microPET P4 model for primates illustrates the gain in sensitivity due to a smaller detector ring diameter but also the changes in NECR.
引用
收藏
页码:737 / 747
页数:11
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