First examples of tetracyclic triterpenoids with a D:B-friedobaccharane skeleton.: A tentative biosynthetic route

被引：19

作者：

Núñez, MJ

López, MR

Jiménez, IA

Moujir, LM

Ravelo, AG

Bazzocchi, IL

机构：

[1] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, San Cristobal la Laguna 38206, Tenerife, Spain

[2] Univ La Laguna, Inst Canario Invest Canc, San Cristobal la Laguna 38206, Tenerife, Spain

[3] Univ La Laguna, Dept Microbiol & Biol Celular, San Cristobal la Laguna 38206, Tenerife, Spain

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 39期

关键词：

tetracyclic triterpenoids; D : B-friedobaccharanes; biosynthetic route; Celastraceae;

D O I：

10.1016/j.tetlet.2004.07.133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Baruol (1) and Leonal (2), first examples of tetracyclic triterpenes possessing a D:B-friedobaccharane skeleton, were isolated from Maytenus blepharodes and M. chiapensis, respectively. Their structures were established by spectroscopic analysis, molecular modeling studies and biogenetic background. The implication of the D:B-friedobaccharenyl cation in the biosynthetic route of baccharane and shionane skeletons is discussed. Baruol exhibited beta-glucuronidase inhibitory activity, a target in the search for hepatoprotective agents. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7367 / 7370

页数：4

共 17 条

[1] Sasanquol, a 3,4-seco-triterpene alcohol from sasanqua oil, and its anti-inflammatory effect [J].