Synthesis of upper rim calix[4]arene divalent glycoclusters via amide bond conjugation

被引：26

作者：

Schädel, U ^{[1
]}

Sansone, F ^{[1
]}

Casnati, A ^{[1
]}

Ungaro, R ^{[1
]}

机构：

[1] Univ Parma, Dipartimento Chim Organ & Ind, I-43100 Parma, Italy

来源：

TETRAHEDRON | 2005年 / 61卷 / 05期

关键词：

calix[4]arene; neoglycoconjugates; glycoside; amide bond;

D O I：

10.1016/j.tet.2004.11.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic routes for linking two sugar units at the upper rim of cone calix[4]arenes, through the formation of amide bonds, have been explored. Steric effects prevent the coupling of calix[4]arene dicarboxylic acid with simple aminoglycosides, whereas the corresponding reaction with carbohydrates bearing a two or three carbon atoms spacer, terminating with a primary amino group, allows the synthesis of several difunctionalized calix[4]arene neoglycoconjugates, attractive in chemical glycobiology and supramolecular chemistry. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1149 / 1154

页数：6

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