Sendai virus-like particles devoid of haemagglutinin-neuraminidase protein infect cells via the human asialoglycoprotein receptor

被引：30

作者：

Leyrer, S

Bitzer, M

Lauer, U

Kramer, J

Neubert, WJ

Sedlmeier, R

机构：

[1] Max Planck Inst Biochem, Abt Virusforsch, D-82152 Martinsried, Germany

[2] Univ Tubingen, Med Klin, Innere Med Abt 1, D-72076 Tubingen, Germany

来源：

JOURNAL OF GENERAL VIROLOGY | 1998年 / 79卷

关键词：

D O I：

10.1099/0022-1317-79-4-683

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Virus-like particles with genetically defined envelope proteins were generated from cDNA in order to examine the requirement of Sendai virus haemagglutinin-neuraminidase (HN) protein for particle formation, and the role of fusion protein (F) in receptor binding and membrane fusion. Characterization of particles devoid of HN protein showed that particle formation was unimpaired by the absence of HN protein, indicating that HN protein is dispensable for virus assembly and budding. Infection studies further demonstrated that virus adsorption and penetration can be mediated solely by the F protein when the human asialoglycoprotein receptor is present at the surface of host cells.

引用

页码：683 / 687

页数：5

共 31 条

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