Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA

被引：179

作者：

Matsumoto, K

Wassarman, KM

Wolffe, AP

机构：

[1] NICHHD, Mol Embryol Lab, NIH, Bethesda, MD 20892 USA

[2] RIKEN, Inst Phys & Chem Res, Bioorgan Chem Lab, Wako, Saitama 35101, Japan

来源：

EMBO JOURNAL | 1998年 / 17卷 / 07期

关键词：

nuclear compartments; ribonuclear protein; splicing control; transcriptional control; translational control;

D O I：

10.1093/emboj/17.7.2107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pathways of synthesis and maturation of premessenger RNA in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm. The transcription of intron-less mRNA in vivo directs this mRNA towards translational silencing. The presence of an intron at the 5' end of the transcript relieves this silencing, whereas an intron at the 3' end further represses translation. These regulatory events are strongly dependent on the transcription of pre-mRNA in the nucleus. The impact of nuclear history on regulatory events in the cytoplasm provides a novel mechanism for the control of gene expression.

引用

页码：2107 / 2121

页数：15

共 95 条

[71] THE 3'-UNTRANSLATED REGIONS OF C-MOS AND CYCLIN MESSENGER-RNAS STIMULATE TRANSLATION BY REGULATING CYTOPLASMIC POLYADENYLATION [J].