Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population

被引：14

作者：

Fidani, L.

Clarimon, J.

Goulas, A.

Hatzitolios, A. I.

Evans, W.

Tsirogianni, E.

Hardy, J.

Kotsis, A.

机构：

[1] Aristotle Univ Thessaloniki, Sch Med, Dept Gen Biol, Thessaloniki, Greece

[2] NIH, NIA, Neurogenet Lab, Bethesda, MD 20892 USA

[3] Aristotle Univ Thessaloniki, Sch Med, Dept Expt Pharmacol, Thessaloniki, Greece

[4] Aristotle Univ Thessaloniki, AHEPA Hosp, Sch Med, First Propedeut Dept Int Med, Thessaloniki, Greece

[5] Reta Lila Weston Inst Neurol, London, England

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2007年 / 14卷 / 07期

基金：

英国医学研究理事会;

关键词：

genetics; gene polymorphism; ischaemic stroke; phosphodiesterase; 4D;

D O I：

10.1111/j.1468-1331.2007.01767.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have examined the association of phosphodiesterase 4D (PDE4D) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818-1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818-1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke.

引用

页码：745 / 749

页数：5

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