Elastin-Like Polypeptides: Biomedical Applications of Tunable Biopolymers

被引：322

作者：

MacEwan, Sarah R. ^{[1
]}

Chilkoti, Ashutosh ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Ctr Biol Inspired Mat & Mat Syst, Durham, NC 27708 USA

来源：

BIOPOLYMERS | 2010年 / 94卷 / 01期

关键词：

elastin-like polypeptides; biomedical applications; polymers; PROTEIN-BASED POLYMERS; INVERSE TEMPERATURE TRANSITION; ENDOTHELIAL-CELL ADHESION; EXTRACELLULAR-MATRIX; RECOMBINANT PROTEINS; CROSS-LINKING; PHASE-TRANSITION; MACROMOLECULAR THERAPEUTICS; MECHANICAL-PROPERTIES; RESPONSIVE POLYMERS;

D O I：

10.1002/bip.21327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Artificial repetitive polypeptides have grown in popularity as a bioinspired alternative to synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of toxicity, and biocompatibility are attractive features of these biopolymers for biological applications. Elastin-like polypeptides (ELPs) are one such class of biopolymers that are of particular interest because of their "smart"-stimuli responsive-properties. Herein, we discuss the genetically encoded design and recombinant synthesis of ELPs that enable precise control of their physicochemical properties and which have led to a wide range of biomedical applications of these biopolymers in the last decade. (C) 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 60-77, 2010.

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收藏

页码：60 / 77

页数：18

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