PKC and the control of localized signal dynamics

被引：351

作者：

Rosse, Carine ^{[1
]}

Linch, Mark ^{[1
]}

Kermorgant, Stephanie ^{[2
]}

Cameron, Angus J. M. ^{[1
]}

Boeckeler, Katrina ^{[1
]}

Parker, Peter J. ^{[1
,3
]}

机构：

[1] Imperial Canc Res Fund, Prot Phosphorylat Lab, London Res Inst Canc Res UK, London WC2A 3PX, England

[2] Barts & London Queen Marys Sch Med & Dent, Canc Res UK Clin Ctr, Dept Tumor Biol, London EC1M 6BQ, England

[3] Kings Coll London, Guys Hosp, Div Canc Studies, London SE1 1UL, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 02期

基金：

英国医学研究理事会;

关键词：

PROTEIN-KINASE-C; T-CELL-ACTIVATION; ALLERGIC AIRWAY INFLAMMATION; EPITHELIAL TIGHT JUNCTION; AMINO-TERMINAL REGION; RECEPTOR INTERNALIZATION; MAMMALIAN HOMOLOG; CDC42; CONTROLS; TURN MOTIF; POLARITY;

D O I：

10.1038/nrm2847

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Networks of signal transducers determine the conversion of environmental cues into cellular actions. Among the main players in these networks are protein kinases, which can acutely and reversibly modify protein functions to influence cellular events. One group of kinases, the protein kinase C (PKC) family, have been increasingly implicated in the organization of signal propagation, particularly in the spatial distribution of signals. Examples of where and how various PKC isoforms direct this tier of signal organization are becoming more evident.

引用

页码：103 / 112

页数：10

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