Adipose tissue expression of IL-18 and HIV associated lipodystrophy

被引：37

作者：

Lindegaard, B ^{[1
]}

Hansen, ABE

Pilegaard, H

Keller, P

Gerstoft, J

Pedersen, BK

Pedersen, K

机构：

[1] Rigshosp, Copenhagen Muscle Res Ctr, Copenhagen, Denmark

[2] Rigshosp, Dept Infect Dis, Copenhagen, Denmark

[3] Univ Copenhagen, August Krogh Inst, DK-2100 Copenhagen, Denmark

来源：

AIDS | 2004年 / 18卷 / 14期

关键词：

D O I：

10.1097/00002030-200409240-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

引用

页码：1956 / 1958

页数：3

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