Adipose tissue expression of IL-18 and HIV associated lipodystrophy

被引：37

作者：

Lindegaard, B ^{[1
]}

Hansen, ABE

Pilegaard, H

Keller, P

Gerstoft, J

Pedersen, BK

Pedersen, K

机构：

[1] Rigshosp, Copenhagen Muscle Res Ctr, Copenhagen, Denmark

[2] Rigshosp, Dept Infect Dis, Copenhagen, Denmark

[3] Univ Copenhagen, August Krogh Inst, DK-2100 Copenhagen, Denmark

来源：

AIDS | 2004年 / 18卷 / 14期

关键词：

D O I：

10.1097/00002030-200409240-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

引用

页码：1956 / 1958

页数：3

共 14 条

[11] High plasma level of interleukin-18 in HIV-infected subjects with lipodystrophy [J].

Lindegaard, B ;

Hansen, ABE ;

Gerstoft, J ;

Pedersen, BK .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2004, 36 (01) :588-593

[12]

Netea MG, 2000, EUR J IMMUNOL, V30, P3057, DOI 10.1002/1521-4141(200010)30:10<3057::AID-IMMU3057>3.0.CO

[13]

2-P

[14] Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia [J].

Netea, MG ;

Fantuzzi, G ;

Kullberg, BJ ;

Stuyt, RJL ;

Pulido, EJ ;

McIntyre, RC ;

Joosten, LAB ;

Van der Meer, JWM ;

Dinarello, CA .

JOURNAL OF IMMUNOLOGY, 2000, 164 (05) :2644-2649

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