Host Determinants of HIV-1 Control in African Americans

被引：122

作者：

Pelak, Kimberly ^{[1
]}

Goldstein, David B. ^{[1
]}

Walley, Nicole M. ^{[1
]}

Fellay, Jacques ^{[1
]}

Ge, Dongliang ^{[1
]}

Shianna, Kevin V. ^{[1
]}

Gumbs, Curtis ^{[1
]}

Gao, Xiaojiang ^{[2
]}

Maia, Jessica M. ^{[1
]}

Cronin, Kenneth D. ^{[1
]}

Hussain, Shehnaz K. ^{[5
]}

Carrington, Mary ^{[2
]}

Michael, Nelson L. ^{[3
]}

Weintrob, Amy C. ^{[4
]}

机构：

[1] Duke Univ, Sch Med, Ctr Human Genome Variat, Durham, NC USA

[2] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick, Frederick, MD 21701 USA

[3] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA

[4] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA

[5] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 08期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; WHOLE-GENOME ASSOCIATION; LINKAGE DISEQUILIBRIUM; VIRAL LOAD; HLA; SUSCEPTIBILITY; INFECTION; GENETICS; MODELS; SET;

D O I：

10.1086/651382

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

引用

页码：1141 / 1149

页数：9

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