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New insights into the roles of agrin

被引：266
作者：
Bezakova, G [1 ]
Ruegg, MA [1 ]
机构：
[1] Univ Basel, Bioctr, Dept Pharmacol Neurobiol, CH-4056 Basel, Switzerland
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 04期
关键词：
D O I：
10.1038/nrm1074
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The heparan sulphate proteoglycan agrin is expressed as several isoforms in various tissues. Agrin is best known as a crucial organizer of postsynaptic differentiation at the neuromuscular junction, but it has recently also been implicated in the formation of the immunological synapse, the organization of the cytoskeleton and the amelioration of function in diseased muscle. So the activities of agrin might be of broader significance than previously anticipated.
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页码：295 / 308
页数：14
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