Catechols from abietic acid:: Synthesis and evaluation as bioactive compounds

被引：90

作者：

Gigante, B

Santos, C

Silva, AM

Curto, MJM

Nascimento, MSJ

Pinto, E

Pedro, M

Cerqueira, F

Pinto, MM

Duarte, MP

Laires, A

Rueff, J

Gonçalves, J

Pegado, MI

Valdeira, ML

机构：

[1] INETI, Dept Technol Ind Quim, P-1649038 Lisbon, Portugal

[2] Univ Porto, Fac Farm, Ctr Estudos Quim Organ Fitoquim & Farmacol, P-4050047 Oporto, Portugal

[3] Univ Nova Lisboa, Fac Ciencias Med, P-1349008 Lisbon, Portugal

[4] Univ Lisbon, Fac Farm, P-1649003 Lisbon, Portugal

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0968-0896(03)00063-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1631 / 1638

页数：8

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[21] HARD ACID AND SOFT NUCLEOPHILE SYSTEMS .3. DEALKYLATION OF ESTERS WITH ALUMINUM HALIDE-THIOL AND ALUMINUM HALIDE SULFIDE SYSTEMS [J].