In vivo fitness costs of different gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques

被引：28

作者：

Loh, Liyen

Batten, C. Jane

Petravic, Janka

Davenport, Miles P.

Kent, Stephen J. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2052, Australia

[3] Univ New S Wales, Prince Wales Hosp, Dept Haematol, Sydney, NSW 2052, Australia

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 10期

关键词：

D O I：

10.1128/JVI.02763-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The kinetics of immune escape and reversion depend upon the efficiency of CD8 cytotoxic T lymphocytes (CTL) and the fitness cost of escape mutations. Escape kinetics of three simian immunodeficiency virus Gag CTL epitopes in pigtail macaques were variable; those of KP9 and AF9 were faster than those of KW9. Kinetics of reversion of escape mutant virus to wild type upon passage to naive major histocompatibility complex-mismatched macaques also varied. Rapid reversion occurred at KP9, gradual biphasic reversion occurred at AF9, and escape mutant KW9 virus failed to revert. The fitness impact of these mutations is KP9 > AF9 > KW9. These data provide insights into the differential utility of CTL in controlling viremia.

引用

页码：5418 / 5422

页数：5

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