The true face of JNK activation in apoptosis

被引：131

作者：

Lin, AN ^{[1
]}

Dibling, B ^{[1
]}

机构：

[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

来源：

AGING CELL | 2002年 / 1卷 / 02期

关键词：

aging; apoptosis; JNK; NF-kappa B; TNF-alpha crosstalk;

D O I：

10.1046/j.1474-9728.2002.00014.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Age-associated changes in apoptotic rates have been observed in a number of different tissues. While the implications of these findings remain unclear, a better understanding of how apoptosis is regulated may further our understanding of the aging process. The role of the JNK pathway in apoptosis has been highly controversial with studies suggesting that it plays a pro-apoptotic, antiapoptotic or no role in this process. Here we discuss what is currently known about JNK's role in apoptosis, highlighting recent findings regarding NF-kappaB-mediated inhibition of JNK activation and its impact on TNF-alpha induced apoptosis.

引用

页码：112 / 116

页数：5

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