Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation

被引：4

作者：

Nielsen, Anne Faerch

Leuschner, Philipp J. F.

Martinez, Javier

机构：

[1] Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus C, Denmark

[2] Austrian Acad Sci, Inst Mol Biotechnol, A-103 Vienna, Austria

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 07期

关键词：

D O I：

10.1038/nsmb0707-572

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are small, noncoding RNAs that regulate gene expression in eukaryotes. The multipurpose protein hnRNP A1, a well- known factor in the regulation of precursor messenger RNA splicing, has now been implicated in the biogenesis of the microRNA miR-18a, shedding further light on the emerging topic of post- transcriptional regulation of microRNA expression.

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页码：572 / 573

页数：2

相关论文

共 20 条

[1] Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[2] Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA [J].

Bonnal, S ;

Pileur, F ;

Orsini, C ;

Parker, F ;

Pujol, F ;

Prats, AC ;

Vagner, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (06) :4144-4153

[3] Alternative splicing:: multiple control mechanisms and involvement in human disease [J].

Cáceres, JF ;

Kornblihtt, AR .

TRENDS IN GENETICS, 2002, 18 (04) :186-193

[4] The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a [J].

Guil, Sonia ;

Caceres, Javier F. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (07) :591-596

[5] Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes - The roles of cytoplasmic location, transcription, and phosphorylation [J].

Hamilton, BJN ;

Burns, CM ;

Nichols, RC ;

Rigby, WFC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (45) :28732-28741

[6]

Hanamura A, 1998, RNA, V4, P430

[7] A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA [J].

Hutvágner, G ;

McLachlan, J ;

Pasquinelli, AE ;

Bálint, É ;

Tuschl, T ;

Zamore, PD .

SCIENCE, 2001, 293 (5531) :834-838

[8] Processing of intronic microRNAs [J].

Kim, Young-Kook ;

Kim, V. Narry .

EMBO JOURNAL, 2007, 26 (03) :775-783

[9] The diverse functions of MicroRNAs in animal development and disease [J].

Kloosterman, Wigard P. ;

Plasterk, Ronald H. A. .

DEVELOPMENTAL CELL, 2006, 11 (04) :441-450

[10] hnRNP complexes: composition, structure, and function [J].

Krecic, AM ;

Swanson, MS .

CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (03) :363-371