Cross-species sequence comparisons: A review of methods and available resources

被引：175

作者：

Frazer, KA ^{[1
]}

Elnitski, L

Church, DM

Dubchak, I

Hardison, RC

机构：

[1] Perlegan Sci, Mountain View, CA 94043 USA

[2] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA

[3] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

[4] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Sci Dept, Berkeley, CA 94720 USA

来源：

GENOME RESEARCH | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1101/gr.222003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the availability of whole-genome sequences for an increasing number of species, we are now faced with the challenge of decoding the information contained within these DNA sequences. Comparative analysis of DNA sequences from multiple species at varying evolutionary distances is a powerful approach for identifying coding and functional noncoding sequences, as well as sequences that are unique for a given organism. In this review, we outline the strategy for choosing DNA sequences from different species for comparative analyses and describe the methods used and the resources publicly available for these studies.

引用

页码：1 / 12

页数：12

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