Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8

被引：16

作者：

Asai, M

Ikeda, M

Akiyama, M

Oshima, I

Shibata, S ^{[1
]}

机构：

[1] Waseda Univ, Sch Human Sci, Dept Pharmacol & Brain Sci, Tokorozawa, Saitama 3591192, Japan

[2] Waseda Univ, Adv Res Ctr Human Sci, Tokorozawa, Saitama 3591192, Japan

[3] Shionogi & Co Ltd, Ctr Expt Anim Dev, Shiga 5203423, Japan

来源：

BRAIN RESEARCH | 2000年 / 876卷 / 1-2期

关键词：

aging; locomotor activity; melatonin; polymerase chain reaction;

D O I：

10.1016/S0006-8993(00)02661-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (tau) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MTI and MT2, receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：220 / 224

页数：5

共 21 条

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