Pharmacological classification of histamine H3 receptor agents across species is attributable to transmembrane 3 sequence differences

被引：6

作者：

Esbenshade, T. A. ^{[1
]}

Estvander, B. R. ^{[1
]}

Miller, T. R. ^{[1
]}

Baranowski, J. L. ^{[1
]}

Sharma, R. ^{[1
]}

Hancock, A. A. ^{[1
]}

Krueger, K. M. ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Dept R4MN, Abbott Pk, IL 60064 USA

来源：

INFLAMMATION RESEARCH | 2007年 / 56卷 / Suppl 1期

关键词：

Histamine; Inverse Agonism; GTPgS Binding; Radioligand Binding Assay; Competition Binding Assay;

D O I：

10.1007/s00011-006-0522-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：S45 / S46

页数：2

共 6 条

[1]

ESBENSHADE T, 2000, CURR PROT PHARM, V1

[2] Histamine H3 receptor antagonists:: Preclinical promise for treating obesity and cognitive disorders [J].

Esbenshade, TA ;

Fox, GB ;

Cowart, MD .

MOLECULAR INTERVENTIONS, 2006, 6 (02) :77-88

[3] Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]:: I.: Potent and selective histamine H3 receptor antagonist with drug-like properties [J].

Esbenshade, TA ;

Fox, GB ;

Krueger, KM ;

Miller, TR ;

Kang, CH ;

Denny, LI ;

Witte, DG ;

Yao, BB ;

Pan, LP ;

Wetter, J ;

Marsh, K ;

Bennani, YL ;

Cowart, MD ;

Sullivan, JP ;

Hancock, AA ;

Esbenshade, T .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (01) :165-175

[4] The histamine H3 receptor:: From gene cloning to H3 receptor drugs [J].

Leurs, R ;

Bakker, RA ;

Timmerman, H ;

de Esch, IJP .

NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (02) :107-U18

[5] Distinct pharmacology of rat and human histamine H3 receptors:: role of two amino acids in the third transmembrane domain [J].

Ligneau, X ;

Morisset, S ;

Tardivel-Lacombe, J ;

Gbahou, F ;

Ganellin, CR ;

Stark, H ;

Schunack, W ;

Schwartz, JC ;

Arrang, JM .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (07) :1247-1250

[6] Molecular modeling and pharmacological analysis of species-related histamine H3 receptor heterogeneity [J].

Yao, BB ;

Hutchins, CW ;

Carr, TL ;

Cassar, S ;

Masters, JN ;

Bennani, YL ;

Esbenshade, TA ;

Hancock, AA .

NEUROPHARMACOLOGY, 2003, 44 (06) :773-786

← 1 →