Genome-wide association studies in diverse populations

被引：418

作者：

Rosenberg, Noah A. ^{[1
,2
,3
,4
]}

Huang, Lucy ^{[2
]}

Jewett, Ethan M. ^{[2
]}

Szpiech, Zachary A. ^{[2
]}

Jankovic, Ivana ^{[2
]}

Boehnke, Michael ^{[4
,5
]}

机构：

[1] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NUCLEOTIDE-POLYMORPHISM PANEL; HUMAN GENETIC-VARIATION; LINKAGE DISEQUILIBRIUM; TCF7L2; GENE; DEMOGRAPHIC HISTORY; ASCERTAINMENT BIAS; LOCAL ANCESTRY; RARE VARIANTS; ADMIXTURE MAP; R(2) MEASURE;

D O I：

10.1038/nrg2760

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.

引用

页码：356 / 366

页数：11

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