A whole lotta jumpin' goin' on:: new transposon tools for vertebrate functional genomics

被引：8

作者：

Ivics, Z ^{[1
]}

Izsvák, Z ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 01期

关键词：

D O I：

10.1016/j.tig.2004.11.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genome sequences of vertebrate model organisms are becoming available, fuelling the next challenging phase of research: annotating all of the genes with functional information. The functional annotation of all of the similar to 35000 genes in mammals will undoubtedly require complementing the technologies of forward and reverse genetics in mutagenesis screens. Two recent articles report on the construction of retrotransposable elements that efficiently 'jump' in mammalian cells. These new elements hold great promise as useful vectors for insertional mutagenesis screens in the mouse.

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页码：8 / 11

页数：4

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