A look at autoimmunity and inflammation in the eye

被引：350

作者：

Caspi, Rachel R. ^{[1
]}

机构：

[1] NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 09期

关键词：

REGULATORY T-CELLS; KOYANAGI-HARADA-DISEASE; HLA CLASS-II; ENDOTOXIN-INDUCED UVEITIS; HLA-A29 TRANSGENIC MICE; RETINAL S-ANTIGEN; NEO-SELF ANTIGEN; BIRDSHOT RETINOCHOROIDOPATHY; OCULAR AUTOIMMUNITY; THYMIC EXPRESSION;

D O I：

10.1172/JCI42440

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.

引用

页码：3073 / 3083

页数：11