Molecular correlates of influenza A H5N1 virus pathogenesis in mice

被引：172

作者：

Katz, JM ^{[1
]}

Lu, XH ^{[1
]}

Tumpey, TM ^{[1
]}

Smith, CB ^{[1
]}

Shaw, MW ^{[1
]}

Subbarao, K ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Influenza Branch, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 22期

关键词：

D O I：

10.1128/JVI.74.22.10807-10810.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Highly pathogenic avian influenza A H5N1 viruses caused an outbreak of human respiratory illness in Hong Kong. Of 15 human H5N1 isolates characterized, nine displayed a high-, five a low-, and one an intermediate-pathogenicity phenotype in the BALB/c mouse model. Sequence analysis determined that five specific amino acids in four proteins correlated with pathogenicity in mice. Alone or in combination, these specific residues are the likely determinants of virulence of human H5N1 influenza viruses in this model.

引用

页码：10807 / 10810

页数：4

共 34 条

[21] CORRELATION OF PATHOGENICITY AND GENE CONSTELLATION OF INFLUENZA-A VIRUSES .2. HIGHLY NEUROVIRULENT RECOMBINANTS DERIVED FROM NON-NEUROVIRULENT OR WEAKLY NEUROVIRULENT PARENT VIRUS-STRAINS
SCHOLTISSEK, C
VALLBRACHT, A
FLEHMIG, B
ROTT, R
[J]. VIROLOGY, 1979, 95 (02) : 492 - 500
[22] Influenza virus neuraminidase activates latent transforming growth factor beta
SchultzCherry, S
Hinshaw, VS
[J]. JOURNAL OF VIROLOGY, 1996, 70 (12) : 8624 - 8629
[23] Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: Amino acid sequence at the HA cleavage site as a marker of pathogenicity potential
Senne, DA
Panigrahy, B
Kawaoka, Y
Pearson, JE
Suss, J
Lipkind, M
Kida, H
Webster, RG
[J]. AVIAN DISEASES, 1996, 40 (02) : 425 - 437
[24] Characterization of avian H5N1 influenza viruses from poultry in Hong Kong
Shortridge, KF
Zhou, NN
Guan, Y
Gao, P
Ito, T
Kawaoka, Y
Kodihalli, S
Krauss, S
Markwell, D
Murti, KG
Norwood, M
Senne, D
Sims, L
Takada, A
Webster, RG
[J]. VIROLOGY, 1998, 252 (02) : 331 - 342
[25] 4 VIRAL GENES INDEPENDENTLY CONTRIBUTE TO ATTENUATION OF LIVE INFLUENZA-A/ANN-ARBOR/6/60 (H2N2) COLD-ADAPTED REASSORTANT VIRUS-VACCINES
SNYDER, MH
BETTS, RF
DEBORDE, D
TIERNEY, EL
CLEMENTS, ML
HERRINGTON, D
SEARS, SD
DOLIN, R
MAASSAB, HF
MURPHY, BR
[J]. JOURNAL OF VIROLOGY, 1988, 62 (02) : 488 - 495
[26] INFLUENZA-VIRUS HEMAGGLUTININ WITH MULTIBASIC CLEAVAGE SITE IS ACTIVATED BY FURIN, A SUBTILISIN-LIKE ENDOPROTEASE
STIENEKEGROBER, A
VEY, M
ANGLIKER, H
SHAW, E
THOMAS, G
ROBERTS, C
KLENK, HD
GARTEN, W
[J]. EMBO JOURNAL, 1992, 11 (07) : 2407 - 2414
[27] Comparisons of highly virulent H5N1 influenza A viruses isolated from humans and chickens from Hong Kong
Suarez, DL
Perdue, ML
Cox, N
Rowe, T
Bender, C
Huang, J
Swayne, DE
[J]. JOURNAL OF VIROLOGY, 1998, 72 (08) : 6678 - 6688
[28] RESCUE OF AN INFLUENZA-A VIRUS WILD-TYPE PB2 GENE AND A MUTANT DERIVATIVE BEARING A SITE-SPECIFIC TEMPERATURE-SENSITIVE AND ATTENUATING MUTATION
SUBBARAO, EK
KAWAOKA, Y
MURPHY, BR
[J]. JOURNAL OF VIROLOGY, 1993, 67 (12) : 7223 - 7228
[29] A SINGLE AMINO-ACID IN THE PB2-GENE OF INFLUENZA-A VIRUS IS A DETERMINANT OF HOST RANGE
SUBBARAO, EK
LONDON, W
MURPHY, BR
[J]. JOURNAL OF VIROLOGY, 1993, 67 (04) : 1761 - 1764
[30] Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness
Subbarao, K
Klimov, A
Katz, J
Regnery, H
Lim, W
Hall, H
Perdue, M
Swayne, D
Bender, C
Huang, J
Hemphill, M
Rowe, T
Shaw, M
Xu, XY
Fukuda, K
Cox, N
[J]. SCIENCE, 1998, 279 (5349) : 393 - 396

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