TNF inhibition and sepsis - sounding a cautionary note

被引:58
作者
Grau, GE
Maennel, DN
机构
[1] Department of Pathology University of Regensburg,
关键词
D O I
10.1038/nm1197-1193
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Conflicting results from anti-TNF trials in sepsis patients suggest that timely administration of TNF inhibitor drugs is crucial.
引用
收藏
页码:1193 / 1195
页数:3
相关论文
共 15 条
[1]   p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock - A randomized controlled multicenter trial [J].
Abraham, E ;
Glauser, MP ;
Butler, T ;
Garbino, J ;
Gelmont, D ;
Laterre, PF ;
Kudsk, K ;
Bruining, HA ;
Otto, C ;
Tobin, E ;
Zwingelstein, C ;
Lesslauer, W ;
Leighton, A .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (19) :1531-1538
[2]   Acute-phase gene expression correlates with intrahepatic tumor necrosis factor-alpha abundance but not with plasma tumor necrosis factor concentrations during sepsis systemic inflammatory response syndrome in the rat [J].
Andrejko, KM ;
Deutschman, CS .
CRITICAL CARE MEDICINE, 1996, 24 (12) :1947-1952
[3]  
Brouckaert P, 1996, J INFLAMM, V47, P18
[4]  
COHEN J, 1995, AM J MED, V99, P455
[5]  
Dellinger RP, 1997, CHEST, V111, P744
[6]   Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment [J].
Docke, WD ;
Randow, F ;
Syrbe, U ;
Krausch, D ;
Asadullah, K ;
Reinke, P ;
VolK, HD ;
Kox, W .
NATURE MEDICINE, 1997, 3 (06) :678-681
[7]   PROTECTIVE EFFECT OF 55-KD BUT NOT 75-KD SOLUBLE TUMOR-NECROSIS-FACTOR RECEPTOR IMMUNOGLOBULIN-G FUSION PROTEINS IN AN ANIMAL-MODEL OF GRAM-NEGATIVE SEPSIS [J].
EVANS, TJ ;
MOYES, D ;
CARPENTER, A ;
MARTIN, R ;
LOETSCHER, H ;
LESSLAUER, W ;
COHEN, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (06) :2173-2179
[8]  
HEUMANN D, 1994, SCI AM SCI MED, V1, P28
[9]  
KWIATKOWSKI D, 1993, Q J MED, V86, P91
[10]   RECOMBINANT SOLUBLE TUMOR-NECROSIS-FACTOR RECEPTOR PROTEINS PROTECT MICE FROM LIPOPOLYSACCHARIDE-INDUCED LETHALITY [J].
LESSLAUER, W ;
TABUCHI, H ;
GENTZ, R ;
BROCKHAUS, M ;
SCHLAEGER, EJ ;
GRAU, G ;
PIGUET, PF ;
POINTAIRE, P ;
VASSALLI, P ;
LOETSCHER, H .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (11) :2883-2886