Signal transduction through NF-κB

被引：1055

作者：

May, MJ ^{[1
]}

Ghosh, S

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New Haven, CT 06520 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0167-5699(97)01197-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inducible transcription factor NF-kappa B plays a central role in the regulation of many immune and inflammatory responses. Advances in our knowledge of the signaling mechanisms that control the activation of NF-kappa B and recent insights into the nature of the I kappa B-kinase represent significant steps forward in understanding this important signaling pathway.

引用

页码：80 / 88

页数：9

共 77 条

[1]

Aizawa S, 1997, J BIOL CHEM, V272, P2042

[2] PHORBOL-ESTER-INDUCED ACTIVATION OF THE NF-KAPPA-B TRANSCRIPTION FACTOR INVOLVES DISSOCIATION OF AN APPARENTLY CYTOPLASMIC NF-KAPPA-B/INHIBITOR COMPLEX [J].

BAEUERLE, PA ;

LENARDO, M ;

PIERCE, JW ;

BALTIMORE, D .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1988, 53 :789-798

[3] The NF-kappa B and I kappa B proteins: New discoveries and insights [J].

Baldwin, AS .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683

[4] TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 LEAD TO PHOSPHORYLATION AND LOSS OF I-KAPPA-B-ALPHA - A MECHANISM FOR NF-KAPPA-B ACTIVATION [J].

BEG, AA ;

FINCO, TS ;

NANTERMET, PV ;

BALDWIN, AS .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (06) :3301-3310

[5]

BROCKMAN JA, 1995, MOL CELL BIOL, V15, P2809

[6] CENTRAL OF I-KAPPA-B-ALPHA PROTEOLYSIS BY SITE-SPECIFIC, SIGNAL-INDUCED PHOSPHORYLATION [J].

BROWN, K ;

GERSTBERGER, S ;

CARLSON, L ;

FRANZOSO, G ;

SIEBENLIST, U .

SCIENCE, 1995, 267 (5203) :1485-1488

[7] MUTUAL REGULATION OF THE TRANSCRIPTIONAL ACTIVATOR NF-KAPPA-B AND ITS INHIBITOR, I-KAPPA-B-ALPHA [J].

BROWN, K ;

PARK, S ;

KANNO, T ;

FRANZOSO, G ;

SIEBENLIST, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2532-2536

[8] TARF6 is a signal transducer for interleukin-1 [J].

Cao, ZD ;

Xiong, J ;

Takeuchi, M ;

Kurama, T ;

Goeddel, DV .

NATURE, 1996, 383 (6599) :443-446

[9] IRAK: A kinase associated with the interleukin-1 receptor [J].

Cao, ZD ;

Henzel, WJ ;

Gao, XO .

SCIENCE, 1996, 271 (5252) :1128-1131

[10] Site-specific phosphorylation of I kappa B alpha by a novel ubiquitination-dependent protein kinase activity [J].

Chen, ZJ ;

Parent, L ;

Maniatis, T .

CELL, 1996, 84 (06) :853-862

← 1 2 3 4 5 6 7 8 →